Understanding 4-AcO-MET and 4-AcO-DMT: A Comprehensive Comparison

The world of psychedelics is vast and diverse, featuring a wide array of substances that each offer unique experiences and effects. Among these, 4-AcO-MET (4-Acetoxy-N-ethyl-N-methyltryptamine) and 4-AcO-DMT (4-Acetoxy-N,N-dimethyltryptamine) have garnered significant interest. Both belong to the tryptamine family and are chemically similar, but they present distinct experiences for users. This article delves into the specifics of each compound, comparing their chemical structures, effects, safety profiles, and legal statuses.

Chemical Structures and Properties

4-AcO-MET

4-AcO-MET is a synthetic tryptamine, a derivative of psilocin. It is structurally similar to 4-AcO-DMT but has an ethyl group attached to the nitrogen atom. This seemingly minor difference in structure can result in different pharmacological properties and subjective effects.

• Chemical Name: 4-Acetoxy-N-ethyl-N-methyltryptamine
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.32 g/mol
• Appearance: Typically a white or off-white powder

4-AcO-DMT

4-AcO-DMT, often referred to as the “synthetic psilocybin,” is a prodrug to psilocin, which means it metabolizes into psilocin in the body. This compound is more widely known and has been the subject of more scientific research compared to 4-AcO-MET.

• Chemical Name: 4-Acetoxy-N,N-dimethyltryptamine
• Molecular Formula: C14H18N2O2
• Molecular Weight: 246.31 g/mol
• Appearance: Typically a white or off-white powder

Mechanism of Action

Both 4-AcO-MET and 4-AcO-DMT are believed to act primarily as agonists of the 5-HT2A receptor, similar to other classical psychedelics. This interaction is thought to be responsible for their psychedelic effects, including altered perception, mood, and cognition.

• 5-HT2A Receptor Agonism: Both compounds bind to and activate the 5-HT2A receptor, leading to a cascade of neurotransmitter releases and changes in brain activity that produce their psychedelic effects.
• Metabolism: 4-AcO-DMT is a prodrug for psilocin, while 4-AcO-MET may be metabolized into 4-HO-MET (4-Hydroxy-N-ethyl-N-methyltryptamine), though more research is needed to confirm this.

Subjective Effects

4-AcO-MET

Users of 4-AcO-MET report a range of effects that are generally described as more stimulating and euphoric compared to 4-AcO-DMT. Common effects include:

• Visual and Auditory Hallucinations: Users often report vivid visual patterns, colors, and auditory distortions.
• Enhanced Mood and Euphoria: There is a general sense of well-being and happiness.
• Increased Sociability: Users may feel more talkative and social.
• Stimulation: Some users experience a stimulating effect, making them feel more energetic and alert.

4-AcO-DMT

4-AcO-DMT is known for producing profound and often introspective experiences. Common effects include:

• Visual and Auditory Hallucinations: Similar to 4-AcO-MET but often described as more intense and profound.
• Deep Introspection: Users often report significant personal and spiritual insights.
• Ego Dissolution: A sense of losing the self or merging with the universe.
• Calm and Relaxation: Some users experience a sense of peace and tranquility.

Dosage and Administration

4-AcO-MET

• Threshold: 5-10 mg
• Light: 10-20 mg
• Common: 20-30 mg
• Strong: 30-50 mg
• Heavy: 50+ mg

4-AcO-DMT

• Threshold: 5-10 mg
• Light: 10-20 mg
• Common: 20-30 mg
• Strong: 30-50 mg
• Heavy: 50+ mg

Both compounds are typically taken orally, but they can also be insufflated (snorted) or taken via other methods, though the latter are less common and often more uncomfortable.

Safety and Side Effects

4-AcO-MET

Common side effects include nausea, anxiety, and paranoia, especially at higher doses. There is limited research on the long-term effects of 4-AcO-MET, so caution is advised.

4-AcO-DMT

Similar to 4-AcO-MET, 4-AcO-DMT can cause nausea, anxiety, and paranoia. It is generally considered safe in the short term when used responsibly, but there is limited information on its long-term effects.

Legal Status

4-AcO-MET

The legal status of 4-AcO-MET varies by country. In the United States, it is unscheduled but could be considered an analogue of psilocin, which is a Schedule I substance. This means it could be prosecuted under the Federal Analogue Act. Other countries have different regulations, so it is important to check local laws.

4-AcO-DMT

4-AcO-DMT also has a varied legal status. In the United States, it is similarly unscheduled but could be considered an analogue of psilocin. In the UK, it is classified as a Class A substance. Other countries have their own specific regulations.

FAQs

What are the main differences between 4-AcO-MET and 4-AcO-DMT?

The primary differences lie in their chemical structure, subjective effects, and duration. 4-AcO-MET is generally described as more stimulating and euphoric, while 4-AcO-DMT tends to produce more profound and introspective experiences.

How long do the effects of 4-AcO-MET and 4-AcO-DMT last?

The duration of effects for both compounds can vary, but generally, 4-AcO-MET lasts between 4-6 hours, while 4-AcO-DMT lasts around 4-6 hours as well.

Are there any risks associated with using 4-AcO-MET and 4-AcO-DMT?

Both compounds can cause anxiety, paranoia, and nausea, especially at higher doses. There is limited research on their long-term effects, so caution and responsible use are advised.

Can 4-AcO-MET and 4-AcO-DMT be detected in a drug test?

Standard drug tests do not typically screen for 4-AcO-MET or 4-AcO-DMT. However, specialized tests could potentially detect these substances.

Are 4-AcO-MET and 4-AcO-DMT legal?

The legal status varies by country. In the United States, both compounds are unscheduled but could be considered analogues of Schedule I substances, making them illegal under certain circumstances.

Conclusion

4-AcO-MET and 4-AcO-DMT are fascinating compounds within the psychedelic tryptamine family, each offering unique experiences and effects. While they share similarities in their chemical structures and mechanisms of action, their subjective effects can differ significantly. Users should approach these substances with caution, respect their potent effects, and be aware of the legal implications of their use.

References

1. Nichols, D. E. (2016). Psychedelics. Pharmacological Reviews, 68(2), 264-355.
2. Halberstadt, A. L., & Geyer, M. A. (2011). Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. Neuropharmacology, 61(3), 364-381.
3. Erowid. (n.d.). 4-AcO-MET. Retrieved from https://www.erowid.org/chemicals/4_acetoxy_met/4_acetoxy_met.shtml
4. Erowid. (n.d.). 4-AcO-DMT. Retrieved from https://www.erowid.org/chemicals/4_acetoxy_dmt/4_acetoxy_dmt.shtml
5. Shulgin, A., & Shulgin, A. (1997). TIHKAL: The Continuation. Transform Press.
6. Passie, T., Seifert, J., Schneider, U., & Emrich, H. M. (2002). The pharmacology of psilocybin. Addiction Biology, 7(4), 357-364.
7. Carhart-Harris, R. L., & Nutt, D. J. (2017). Serotonin and brain function: a tale of two receptors. Journal of Psychopharmacology, 31(9), 1091-1120.

This comprehensive article provides an in-depth comparison of 4-AcO-MET and 4-AcO-DMT, highlighting their chemical properties, mechanisms of action, subjective effects, safety profiles, and legal statuses. The inclusion of FAQs addresses common queries, offering readers a thorough understanding of these intriguing substances.